>
产品中心 >
Small_molecule >
Medchemexpress/Pepstatin（同义词：Pepstatin A；异戊酰缬氨酸/羟基缬氨酸）/HY-P0018/10mg
| Description |
Pepstatin is a potent inhibitor of aspartyl proteases, and inhibits the aspartic proteases cathepsin D, pepsin, and renin. |
|---|---|
| In Vivo |
A low dose of pepstatin shows an inhibition of edema formation, and intraperitoneal injection of 1.25 mg/kg of pepstatin causes a 30% inhibition with a a very low toxicity[1]. Pepstatin increases LC3-II levels, while it is reverted by 3-methyladenine (3-MA)[2]. |
| References |
|
| Preparing Stock Solutions |
Please refer to the solubility information to select the appropriate solvent.
|
||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| References |
|
| Molecular Weight |
685.89 |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Formula |
C₃₄H₆₃N₅O₉ |
||||||||||||
| CAS No. |
26305-03-3 |
||||||||||||
| Storage |
|
||||||||||||
| Shipping | Room temperature in continental US; may vary elsewhere |
||||||||||||
| Solvent & Solubility |
DMSO: ≥ 25 mg/mL
* "<1 mg/ml"="" means="" slightly="" soluble="" or="" insoluble.="" "≥"="" means="" soluble,="" but="" saturation=""> |
Purity: 98.45%
COA (94 KB) LCMS (1269 KB)
Handling Instructions (1252 KB)-
[1]. Umezawa H, et al. Pepstatin, a new pepsin inhibitor produced by Actinomycetes. J Antibiot (Tokyo). 1970 May;23(5):259-62.
[2]. Raquel T. Lima, et al. Modulation of Autophagy by a Thioxanthone Decreases the Viability of Melanoma Cells. Molecules 2016, 21(10), 1343
