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当前位置： 首页 > 产品中心 > Small_molecule > Medchemexpress/褪黑素（同义词：N-乙酰-5-甲氧基色胺）/HY-B0075/1g
商品详细Medchemexpress/褪黑素（同义词：N-乙酰-5-甲氧基色胺）/HY-B0075/1g
Medchemexpress/褪黑素（同义词：N-乙酰-5-甲氧基色胺）/HY-B0075/1g
Medchemexpress/褪黑素（同义词：N-乙酰-5-甲氧基色胺）/HY-B0075/1g
商品编号： HY-B0075-10mM*1mLinDMSO
品牌： MedChemExp
市场价： ¥1320.00
美元价： 792.00
产地： 美国(厂家直采)
公司：
产品分类： 小分子
公司分类： Small_molecule
联系Q Q： 3392242852
电话号码： 4000-520-616
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商品介绍
Melatonin,ahormoneproducedinthebrain,isapotentmelatoninreceptoractivator,andpossessesimportantantioxidativeandanti-inflammatoryproperties.
Description

Melatonin,ahormoneproducedinthebrain,isapotentmelatoninreceptoractivator,andpossessesimportantantioxidativeandanti-inflammatoryproperties.

InVivo

MelatoninincreasesthelevelsofactivatedPTEN,RSK-1,mTORandAMPKαkinases,mildlyinhibitsERK-1/2phosphorylationandBadphosphorylation,significantlyinhibitsphosphorylationsofS6RibosomalProtein,4E-BP1,GSK-3αandGSK-3β,andslightlyincreasesPRAS40phosphorylationinanimals[1].MelatoninamelioratestheneurotoxiciyandastrocyteactivationinducedbyAβ1-42inthecerebralcortex.MelatoninalsoblocksthereductioninReelinandDab1expressioninducedbyAβ1-42[2].MelatonintreatmentandlackofNLRP3-/-sharesimilarinhibitionofNF-κBandNLRP3signalingpathwayinmice.MelatonintreatmentandlackofNLRP3-/-sharesomepatternsofclockgenesexpression,andimprovecardiomyocytesmorphologyinmice[3].

ClinicalTrial
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References

  • [1].KilicU,etal.ParticularphosphorylationofPI3K/AktonThr308viaPDK-1andPTENmediatesmelatonin"sneuroprotectiveactivityafterfocalcerebralischemiainmice.RedoxBiol.2017Apr5;12:657-665.

    [2].HuC,etal.NeuroprotectiveeffectofmelatoninonsolubleAβ1-42-inducedcorticalneurodegenerationviaReelin-Dab1signalingpathway.NeurolRes.2017Apr7:1-11

    [3].RahimI,etal.MelatoninadmiNISTrationtowild-typemiceandnon-treatedNLRP3mutantmicesharesimilarinhibitionoftheinflammatoryresponseduringsepsis.JPinealRes.2017Mar31.

PreparingStockSolutions
ConcentrationVolumeMass1mg5mg10mg
1mM4.3051mL21.5257mL43.0515mL
5mM0.8610mL4.3051mL8.6103mL
10mM0.4305mL2.1526mL4.3051mL
Pleaserefertothesolubilityinformationtoselecttheappropriatesolvent.
AnimalAdministration
[1]

Melatoninisdissolvedin0.9%isotonicsaline/5%ethanolataconcentrationof4mg/kg.

AtotaloftwosetsofadultmaleC57BL/6jmiceweighing21-26garerandomlyassignedtooneoffourgroupsandtreatedwithintraperitoneal(i.p.)deliveryof(i)vehicle(50μLisotonicsaline/5%ethanol),(ii)melatonin(4mg/kg,dissolvedin0.9%isotonicsaline/5%ethanol),(iii)Wortmannin,and(iv)melatonin/Wortmanninimmediatelyafterreperfusion.Inthefirstset,miceareexposedto30minoffocalcerebralischemia(FCI)and72hreperfusionfortheevaluationofdisseminateischemicinjuryinthestriatum,andsignalingpathwayanalysis(n=7pergroup).Thesecondgroupofmiceisexposedto90minofFCIand24hreperfusionfortheanalysisofinfarctdevelopment,brainswellingandIgGextravasation(n=7pergroup).MCEhasnotindependentlyconfirmedtheaccuracyofthesemethods.Theyareforreferenceonly.

References

  • [1].KilicU,etal.ParticularphosphorylationofPI3K/AktonThr308viaPDK-1andPTENmediatesmelatonin"sneuroprotectiveactivityafterfocalcerebralischemiainmice.RedoxBiol.2017Apr5;12:657-665.

    [2].HuC,etal.NeuroprotectiveeffectofmelatoninonsolubleAβ1-42-inducedcorticalneurodegenerationviaReelin-Dab1signalingpathway.NeurolRes.2017Apr7:1-11

    [3].RahimI,etal.Melatoninadministrationtowild-typemiceandnon-treatedNLRP3mutantmicesharesimilarinhibitionoftheinflammatoryresponseduringsepsis.JPinealRes.2017Mar31.

MolecularWeight

232.28

Formula

C₁₃H₁₆N₂O₂

CASNo.

73-31-4

Storage
Powder-20°C3years
 4°C2years
Insolvent-80°C6months
 -20°C1month
Shipping

RoomtemperatureincontinentalUS;mayvaryelsewhere

Solvent&Solubility

DMSO:≥68mg/mL

*"<1 mg/ml"="" means="" slightly="" soluble="" or="" insoluble.="" "≥"="" means="" soluble,="" but="" saturation="">

Purity:>98.0%