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当前位置: 首页 > 产品中心 > Small_molecule > Medchemexpress/Pilocarpine Hydrochloride/HY-B0726/500mg
商品详细Medchemexpress/Pilocarpine Hydrochloride/HY-B0726/500mg
Medchemexpress/Pilocarpine Hydrochloride/HY-B0726/500mg
Medchemexpress/Pilocarpine Hydrochloride/HY-B0726/500mg
商品编号: HY-B0726-100mg
品牌: MedChemExp
市场价: ¥1200.00
美元价: 720.00
产地: 美国(厂家直采)
公司:
产品分类: 小分子
公司分类: Small_molecule
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
PilocarpineHClisanonselectivemuscarinicacetylcholinereceptoragoNISTusedtoproduceanexperimentalmodelofepilepsy.
Description

PilocarpineHClisanonselectivemuscarinicacetylcholinereceptoragonistusedtoproduceanexperimentalmodelofepilepsy.Target:mAChRPilocarpineisaparasympathomimeticalkaloidobtainedfromtheleavesoftropicalAmericanshrubsfromthegenusPilocarpus.Itisanon-selectivemuscarinicreceptoragonistintheparasympatheticnervoussystem,whichactstherapeuticallyatthemuscarinicacetylcholinereceptorM3duetoitstopicalapplication,e.g.,inglaucomaandxerostomia.Pilocarpineactsonasubtypeofmuscarinicreceptor(M3)foundontheirissphinctermuscle,causingthemuscletocontractandengageinmiosis[1].Pilocarpinealsoactsontheciliarymuscleandcausesittocontract.Whentheciliarymusclecontracts,itopensthetrabecularmeshworkthroughincreasedtensiononthescleralspur.Thisactionfacilitatestheratethataqueoushumorleavestheeyetodecreaseintraocularpressure.Inophthalmology,pilocarpineisalsousedtoreducethepossibilityofglareatnightfromlightswhenthepatienthasundergoneimplantationofphakicintraocularlenses;theuseofpilocarpinewouldreducethesizeofthepupils,relievingthesesymptoms.Themostcommonconcentrationforthisuseispilocarpine1%,theweakestconcentration.Pilocarpineisalsousedtotreatdrymouth(xerostomia)whichcanoccur,forexample,asasideeffectofrADIationtherapyforheadandneckcancers.Pilocarpinestimulatesthesecretionoflargeamountsofsalivaandsweat[2].

ClinicalTrial
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References
  • [1].Maslanski,J.A.,etal.,Assessmentofthemuscarinicreceptorsubtypesinvolvedinpilocarpine-inducedseizuresinmice.NeurosciLett,1994.168(1-2):p.225-8.

    [2].Mayorga,A.J.,etal.,Characterizationofthemuscarinicreceptorsubtypemediatingpilocarpine-inducedtremulousjawmovementsinrats.EurJPharmacol,1999.364(1):p.7-11.

PreparingStockSolutions
ConcentrationVolumeMass1mg5mg10mg
1mM4.0863mL20.4315mL40.8630mL
5mM0.8173mL4.0863mL8.1726mL
10mM0.4086mL2.0432mL4.0863mL
Pleaserefertothesolubilityinformationtoselecttheappropriatesolvent.
References
  • [1].Maslanski,J.A.,etal.,Assessmentofthemuscarinicreceptorsubtypesinvolvedinpilocarpine-inducedseizuresinmice.NeurosciLett,1994.168(1-2):p.225-8.

    [2].Mayorga,A.J.,etal.,Characterizationofthemuscarinicreceptorsubtypemediatingpilocarpine-inducedtremulousjawmovementsinrats.EurJPharmacol,1999.364(1):p.7-11.

MolecularWeight

244.72

Formula

C₁₁H₁₇ClN₂O₂

CASNo.

54-71-7

Storage
Powder-20°C3years
 4°C2years
Insolvent-80°C6months
 -20°C1month
Shipping

RoomtemperatureincontinentalUS;mayvaryelsewhere

Solvent&Solubility

H2O:≥37mg/mL;DMSO:6.8mg/mL

*"<1 mg/ml"="" means="" slightly="" soluble="" or="" insoluble.="" "≥"="" means="" soluble,="" but="" saturation="">

Purity:99.92%