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当前位置： 首页 > 产品中心 > Small_molecule > Medchemexpress/MPTP盐酸盐/HY-15608/50mg
商品详细Medchemexpress/MPTP盐酸盐/HY-15608/50mg
Medchemexpress/MPTP盐酸盐/HY-15608/50mg
Medchemexpress/MPTP盐酸盐/HY-15608/50mg
商品编号： HY-15608
品牌： MedChemExp
市场价： ¥3000.00
美元价： 1800.00
产地： 美国(厂家直采)
公司：
产品分类： 小分子
公司分类： Small_molecule
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商品介绍
MPTP(hydrochloride)isaprodrugtotheneurotoxinMPPwhichcausespermanentsymptomsofParkinson"sdisease.

CustomerValidation

  • •BrainRes.2016Jul1;1642:546-552.
Description

MPTP(hydrochloride)isaprodrugtotheneurotoxinMPPwhichcausespermanentsymptomsofParkinson"sdisease.

InVitro

Pretreatmentwith50mM4-phenylpyridine,reducesIC50(concentrationfor50%inhibitionoftwitchamplitude)valuesofMPTPfrom53to18mMandd-tubocurarinefrom0.7to0.3mM,respectively,inmousephrenicnerve-diaphragm[3].

InVivo

ThetoxiceffectofMPTPcanbecompletelyabolishedinvivobytreatmentwithamonoamineoxidaseinhibitorandpotentiatedbyaninhibitorofcatechol-O-methyltransferase[1].AllopurinolpotentiatedtheMPTP(35mg/kg)-induceddecreaseintheDOPAC+HVA/DAratioandincreaseinstriatalAAoxidationoftherat[2].Gas1expressionsaresignificantlyelevatedinthemajorityofthereactiveastrocytesofthebrainswithLPSorMPTPinsultsinanimalmodels[4].

References

  • [1].LangstonJW,IrwinI.MPTPNeurotoxicity:AnOverviewandCharacterizationofPhasesofToxicity.II.SelectiveAccumulationofMPPintheSubstantiaNigra:AKeytoNeurotoxicity(Question).LifeSci.,1985,36,No.3,201-12.

    [2].DesoleMS,etal.FurtherinvestigationofallopurinoleffectsonMPTP-inducedoxidativestressinthestriatumandbrainstemoftherat.Source:Pharmacol.Biochem.Behav.,1996,54,No.2,377-83.

    [3].HsuKS,etal.PotentiationofMPTPby4-PhenylpyridineontheNeuromuscularBlockadeinMousePhrenicNerve-Diaphragm.Neuropharmacology,1993,32,No.9,877-83.

    [4].SunXL,etal.Gas1up-regulationisinducIBLeandcontributestocellapoptosisinreactiveastrocytesinthesubstantianigraofLPSandMPTPmodels.JNeuroinflammation.2016Jul8;13(1):180.

PreparingStockSolutions
ConcentrationVolumeMass1mg5mg10mg
1mM4.7683mL23.8413mL47.6826mL
5mM0.9537mL4.7683mL9.5365mL
10mM0.4768mL2.3841mL4.7683mL
Pleaserefertothesolubilityinformationtoselecttheappropriatesolvent.
AnimalAdmiNISTration
[4]

MPTPisformulatedin0.9%saline.

ForthepreparationoftheLPSratmodelandtheMPTPmousemodel,thetreatmentsoftheanimalsareperformed.Briefly,adultratsreceiveunilateralinjectionsofLPS(0.5 μLof10 μg/μLdilutedin0.9%saline)intothemedialforebrainbundle(MFB)atthefollowingcoordinates,AP-4.2 mm,L1.5 mm,andV7.8 mm,andintothecontralateralsidewiththesamevolumeof0.9%saline.AdultmiceareadministeredintraperitonealinjectionsofMPTPof25 mg/kgperdayforfivecontinuousdays,andthesamevolumeofsalineisinjectedasacontrol.Alltheanimalsaresacrificedatweek1,2,3,or4aftertheLPSorMPTPinjections.Thebrainsamplesarecollectedforthesubsequentimmunohistochemistryandwesternblotexperiments.MCEhasnotindependentlyconfirmedtheaccuracyofthesemethods.Theyareforreferenceonly.

References

  • [1].LangstonJW,IrwinI.MPTPNeurotoxicity:AnOverviewandCharacterizationofPhasesofToxicity.II.SelectiveAccumulationofMPPintheSubstantiaNigra:AKeytoNeurotoxicity(Question).LifeSci.,1985,36,No.3,201-12.

    [2].DesoleMS,etal.FurtherinvestigationofallopurinoleffectsonMPTP-inducedoxidativestressinthestriatumandbrainstemoftherat.Source:Pharmacol.Biochem.Behav.,1996,54,No.2,377-83.

    [3].HsuKS,etal.PotentiationofMPTPby4-PhenylpyridineontheNeuromuscularBlockadeinMousePhrenicNerve-Diaphragm.Neuropharmacology,1993,32,No.9,877-83.

    [4].SunXL,etal.Gas1up-regulationisinducibleandcontributestocellapoptosisinreactiveastrocytesinthesubstantianigraofLPSandMPTPmodels.JNeuroinflammation.2016Jul8;13(1):180.

MolecularWeight

209.72

Formula

C₁₂H₁₆ClN

CASNo.

23007-85-4

Storage
Powder-20°C3years
 4°C2years
Insolvent-80°C6months
 -20°C1month
Shipping

RoomtemperatureincontinentalUS;mayvaryelsewhere

Solvent&Solubility

DMSO:12mg/mL

*"<1 mg/ml"="" means="" slightly="" soluble="" or="" insoluble.="" "≥"="" means="" soluble,="" but="" saturation="">

Purity:99.16%