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当前位置： 首页 > 产品中心 > Small_molecule > Medchemexpress/Prostaglandin E1(Synonyms: PGE1)/HY-B0131/50mg
商品详细Medchemexpress/Prostaglandin E1(Synonyms: PGE1)/HY-B0131/50mg
Medchemexpress/Prostaglandin E1(Synonyms: PGE1)/HY-B0131/50mg
Medchemexpress/Prostaglandin E1(Synonyms: PGE1)/HY-B0131/50mg
商品编号： HY-B0131-5mg
品牌： MedChemExp
市场价： ¥1440.00
美元价： 864.00
产地： 美国(厂家直采)
公司：
产品分类： 小分子
公司分类： Small_molecule
联系Q Q： 3392242852
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商品介绍
ProstaglandinE1(AlprostADIl)isaprostaglandin,whichisusedinthetreatmentoferectiledysfunctionandhasvasodilatoryproperties.
Description

ProstaglandinE1(Alprostadil)isaprostaglandin,whichisusedinthetreatmentoferectiledysfunctionandhasvasodilatoryproperties.Target:ProstaglandinReceptorProstaglandinE1(PGE1),knownpharmaceuticallyasalprostadil,isaprostaglandin.Itisadrugusedinthetreatmentoferectiledysfunctionandhasvasodilatoryproperties.Inhealthyhumans,prostaglandinE1isbiosynthesized"ondemand"atitsintendedsiteofactionfromdihomo-γ-linolenicacid.Alprostadilisanaturallyoccurringprostaglandinusedinthetreatmentofinfantswithcongenitalheartdefectstomaintainthepatencyoftheductusarteriosusuntilpalliativeorcorrectivesurgerycanbeperformed.Ininfantswithdefectsrestrictingpulmonarybloodflow(cyanotic),alprostadilimprovesarterialbloodoxygenation.Ininfantswithdefectsrestrictingsystemicbloodflow,alprostadilimprovesarterialbloodpH,urineoutput,andfemoralarterialpulses.AlprostadilisadmiNISTeredbycontinuousintraarterialorintravenousinfusion,usuallyatastartingdoseof0.1microgram/kg/min,withmaintenancedosesaslowas0.002microgram/kg/min.

ClinicalTrial
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References

  • [1].CawelloW,etal.Doseproportionalpharmacokineticsofalprostadil(prostaglandinE1)inhealthyvolunteersfollowingintravenousinfusion.BrJClinPharmacol.1995Sep;40(3):273-6.

    [2].RoehlSL,etal.Alprostadil(ProstinVRPediatricSterileSolution,TheUpjohnCompany).DrugIntellClinPharm.1982Nov;16(11):823-32.

    [3].HardingLM,etal.Comparisonofaneedle-freehigh-pressureinjectionsystemwithneedle-tippedinjectionofintracavernosalalprostadilforerectiledysfunction.IntJImpotRes.2002Dec;14(6):498-501.

PreparingStockSolutions
ConcentrationVolumeMass1mg5mg10mg
1mM2.8210mL14.1052mL28.2103mL
5mM0.5642mL2.8210mL5.6421mL
10mM0.2821mL1.4105mL2.8210mL
Pleaserefertothesolubilityinformationtoselecttheappropriatesolvent.
References

  • [1].CawelloW,etal.Doseproportionalpharmacokineticsofalprostadil(prostaglandinE1)inhealthyvolunteersfollowingintravenousinfusion.BrJClinPharmacol.1995Sep;40(3):273-6.

    [2].RoehlSL,etal.Alprostadil(ProstinVRPediatricSterileSolution,TheUpjohnCompany).DrugIntellClinPharm.1982Nov;16(11):823-32.

    [3].HardingLM,etal.Comparisonofaneedle-freehigh-pressureinjectionsystemwithneedle-tippedinjectionofintracavernosalalprostadilforerectiledysfunction.IntJImpotRes.2002Dec;14(6):498-501.

MolecularWeight

354.48

Formula

C₂₀H₃₄O₅

CASNo.

745-65-3

Storage

4°C,storedundernitrogen

Shipping

RoomtemperatureincontinentalUS;mayvaryelsewhere

Solvent&Solubility

10mMinDMSO

*"<1 mg/ml"="" means="" slightly="" soluble="" or="" insoluble.="" "≥"="" means="" soluble,="" but="" saturation="">

Purity:>98.0%