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Medchemexpress/Dexamethasone(Synonyms: MK 125; NSC 34521; Prednisolone F)/HY-14648/5g
Description | Dexamethasoneisaglucocorticoidreceptoragonist. |
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IC50&Target | Glucocorticoidreceptor[1] |
InVitro | Dexamethasoneregulatesseveraltranscriptionfactors,includingactivatorprotein-1,nuclearfactor-AT,andnuclearfactor-kB,leADIngtotheactivationandrepressionofkeygenesinvolvedintheinflammatoryresponse[1].Dexamethasonepotentlyinhibitsgranulocyte-macrophagecolonystimulatingfactor(GM-CSF)releasefromA549cellswithEC50of2.2nM.Dexamethasone(EC50=36nM)inducestranscriptionoftheβ2-receptorisfoundtocorrelatewithglucocorticoidreceptor(GR)DNAbindingandoccurredat10-100foldhigherconcentrationsthantheinhibitionofGM-CSFrelease.Dexamethasone(IC50=0.5nM)inhibitsa3×κB(NF-κB,IκBα,andI-κBβ),whichisassociatedwithinhibitionofGM-CSFrelease[2]. |
InVivo | IthaspreviouslybeenreportedthattreatmentwithDexamethasoneatadoseof2×5mg/kgefficientlyinhibitslipopolysaccharide(LPS)-inducedinflammation.Inourexperimentalsystem,treatmentwithasingledoseofDexamethasone10mg/kg(i.p.)significantlydecreasesrecruitmentofgranulocytesaswellasspontaneousproductionofoxygenradicalscomparedwithanimalsexposetoLPSandinjectedwithsolventalone(saline).Theeffectsarestatisticallysignificantwhenadministeredboth1hbeforeand1hafterinhalationofLPS.ThenumberofgranulocytesinBALFdecreasedtolevelscomparabletohealthyanimals(givenanaerosolofwater)[3].RatstreatedwithDexamethasoneconsumelessfoodandweighedlessthancontrolrats.Treatedratsalsoweighlessthanpair-fedanimalsthoughtheirfoodintakeissimilar.FivedaysofDexamethasoneinjectionresultinasignificantincreaseinboththelivermass(+42%)andthelivertobodyweightratio(+65%).Thewetweightofgastrocnemiusmuscledecreases20%after5daysoftreatment,butitremainsunaffectedrelativetobodyweight(g/100gbodyweight),indicatingthatmuscleweightlossparalleledbodyweightloss[4]. |
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PreparingStockSolutions |
Pleaserefertothesolubilityinformationtoselecttheappropriatesolvent. | ||||||||||||||||
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AnimalAdministration [3][4] | Dexamethasoneispreparedinsaline(Mice)[3]. Mice[3] | ||||||||||||||||
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MolecularWeight | 392.46 | ||||||||||||
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Formula | C₂₂H₂₉FO₅ | ||||||||||||
CASNo. | 50-02-2 | ||||||||||||
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Shipping | RoomtemperatureincontinentalUS;mayvaryelsewhere | ||||||||||||
Solvent&Solubility | DMSO:≥56mg/mL Invivo:insolubleinsaline(<0.1=""> *"<1 mg/ml"="" means="" slightly="" soluble="" or="" insoluble.="" "≥"="" means="" soluble,="" but="" saturation="">1> | ||||||||||||
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Purity:98.70%