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当前位置： 首页 > 产品中心 > Small_molecule > Medchemexpress/盐酸万古霉素/HY-17362/10mM*1mL二甲基亚砜
商品详细Medchemexpress/盐酸万古霉素/HY-17362/10mM*1mL二甲基亚砜
Medchemexpress/盐酸万古霉素/HY-17362/10mM*1mL二甲基亚砜
Medchemexpress/盐酸万古霉素/HY-17362/10mM*1mL二甲基亚砜
商品编号： HY-17362-10mM*1mLinDMSO
品牌： MedChemExp
市场价： ¥1320.00
美元价： 792.00
产地： 美国(厂家直采)
公司：
产品分类： 小分子
公司分类： Small_molecule
联系Q Q： 3392242852
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商品介绍
Vancomycinhydrochlorideisanantibioticforthetreatmentofbacterialinfections.
Description

Vancomycinhydrochlorideisanantibioticforthetreatmentofbacterialinfections.

InVitro

Vancomycinisalargeglycopeptidecompoundwithamolecularweightof1450Da[1].Vancomycinisauniqueglycopeptidestructurallyunrelatedtoanycurrentlyavailableantibiotic.ItalsohasauniquemodeofactioninhibitingthesecondstageofcellwallsynthesisofsusceptIBLebacteria.VancomycinisactiveagainstalargenumberofspeciesofGram-positivebacteria,suchasStaphylococcusaureus,Staph.epidermidis,Str.agalactiae,Str.bovis,Str.mutans,viridansstreptococci,enterococci[2].

InVivo

VancomycinisadmiNISTeredintravenously,withastandardinfusiontimeofatleast1h,tominimizeinfusion-relatedadverseeffects.Subjectswithnormalcreatinineclearance,vancomycinhasanα-distributionphaseof30minto1handaβ-eliminationhalf-lifeof6-12h.Thevolumeofdistributionis0.4–1L/kg.Thebindingofvancomycintoproteinrangesfrom10%to50%.Factorsthataffecttheoverallactivityofvancomycinincludeitstissuedistribution,inoculumsize,andprotein-bindingeffects[1].Vancomycintreatmentofinfectedmiceisassociatedwithimprovedclinical,diarrhea,andhistopathologyscoresandsurvivalduringtreatment[3].

References

  • [1].RybakMJ,etal.Thepharmacokineticandpharmacodynamicpropertiesofvancomycin.ClinInfectDis.2006Jan1;42Suppl1:S35-9.

    [2].WatanakunakornC,etal.Modeofactionandin-vitroactivityofvancomycin.JAntimicrobChemother.1984Dec;14SupplD:7-18.

    [3].WarrenCA,etal.Vancomycintreatment"sassociationwithdelayedintestinaltissueinjury,clostridialovergrowth,andrecurrenceofClostridiumdifficileinfectioninmice.AntimicrobAgentsChemother.2013Feb;57(2):689-96.

PreparingStockSolutions
ConcentrationVolumeMass1mg5mg10mg
1mM0.6731mL3.3654mL6.7307mL
5mM0.1346mL0.6731mL1.3461mL
10mM0.0673mL0.3365mL0.6731mL
Pleaserefertothesolubilityinformationtoselecttheappropriatesolvent.
AnimalAdministration
[3]

Mouse:Onesetofexperimentsisperformedinwhichinfectedmicearetreatedwithvancomycin(50mg/kg)dailyfor1,2,3,or5daysandareobservedfor21dayspostinfectionorwithvancomycin(20mg/kg)dailyforeither5or10daysandmonitoringfor15dayspostinfection[3].MCEhasnotindependentlyconfirmedtheaccuracyofthesemethods.Theyareforreferenceonly.

References

  • [1].RybakMJ,etal.Thepharmacokineticandpharmacodynamicpropertiesofvancomycin.ClinInfectDis.2006Jan1;42Suppl1:S35-9.

    [2].WatanakunakornC,etal.Modeofactionandin-vitroactivityofvancomycin.JAntimicrobChemother.1984Dec;14SupplD:7-18.

    [3].WarrenCA,etal.Vancomycintreatment"sassociationwithdelayedintestinaltissueinjury,clostridialovergrowth,andrecurrenceofClostridiumdifficileinfectioninmice.AntimicrobAgentsChemother.2013Feb;57(2):689-96.

MolecularWeight

1485.72

Formula

C₆₆H₇₆Cl₃N₉O₂₄

CASNo.

1404-93-9

Storage
Powder-20°C3years
 4°C2years
Insolvent-80°C6months
 -20°C1month
Shipping

RoomtemperatureincontinentalUS;mayvaryelsewhere

Solvent&Solubility

DMSO:24mg/mL

*"<1 mg/ml"="" means="" slightly="" soluble="" or="" insoluble.="" "≥"="" means="" soluble,="" but="" saturation="">

Purity:>98.0%