Medchemexpress/茴香霉素（同义词：鞭毛蛋白；武宁美素C）/HY-18982/10mM*1mL二甲基亚砜-免疫在线蚂蚁淘旗下平台

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商品详细Medchemexpress/茴香霉素（同义词：鞭毛蛋白；武宁美素C）/HY-18982/10mM*1mL二甲基亚砜

Medchemexpress/茴香霉素（同义词：鞭毛蛋白；武宁美素C）/HY-18982/10mM*1mL二甲基亚砜

商品编号： HY-18982-10mM*1mLinDMSO

品牌： MedChemExp

市场价： ¥1320.00

美元价： 792.00

产地：美国(厂家直采)

公司：

产品分类：小分子

公司分类： Small_molecule

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Anisomycinisapyrrolidineantibiotic,actsasananti-fungalantibioticwhichinhibitsProteinSynthesis,alsoisapotentactivatorofSAPKs/JNKs.

Description	Anisomycinisapyrrolidineantibiotic,actsasananti-fungalantibioticwhichinhibitsProteinSynthesis,alsoisapotentactivatorofSAPKs/JNKs.Target:antibioticinvitro:AnisomycininhibitsEACcellproliferationinconcentration-dependentmanner.[2]Anisomycin(3μM)decreasesproteinsynthesisinMDA16andMDA-MB-468cells,andreducescolonyformationbyMDA-MB-468cells.AnisomycincausesanincreaseinthenumberofapoptoticcellsinMDA-MB-468cultures,butnotinMDA16cultures.AnisomycinactivesJNKphosphorylationinMDA-MB-468cells.[3]invivo:PeritumoraladmiNISTrationofanisomycin(5mg/kg)significantlysuppressesEhrlichascitescarcinoma(EAC)growthresultinginthesurvivalofapproximately60%ofthemice90daysafterEACinoculation.[2]
References	[1].DubueJD,etal.IntrahippocampalAnisomycinImpairsSpatialPerformanceontheMorrisWaterMaze.JNeurosci.2015Aug5;35(31):11118-11124. [2].YouP,etal.InvitroandinvivoevaluationofanisomycinagainstEhrlichascitescarcinoma.OncolRep.2013,29(6),2227-2236. [3].MonaghanD,etal.InhibitionofproteinsynthesisandJNKactivationarenotrequiredforcelldeathinducedbyanisomycinandanisomycinanalogues.BiochemBiophysResCommun.2014Jan10;443(2):761-767.

Description

Anisomycinisapyrrolidineantibiotic,actsasananti-fungalantibioticwhichinhibitsProteinSynthesis,alsoisapotentactivatorofSAPKs/JNKs.Target:antibioticinvitro:AnisomycininhibitsEACcellproliferationinconcentration-dependentmanner.[2]Anisomycin(3μM)decreasesproteinsynthesisinMDA16andMDA-MB-468cells,andreducescolonyformationbyMDA-MB-468cells.AnisomycincausesanincreaseinthenumberofapoptoticcellsinMDA-MB-468cultures,butnotinMDA16cultures.AnisomycinactivesJNKphosphorylationinMDA-MB-468cells.[3]invivo:PeritumoraladmiNISTrationofanisomycin(5mg/kg)significantlysuppressesEhrlichascitescarcinoma(EAC)growthresultinginthesurvivalofapproximately60%ofthemice90daysafterEACinoculation.[2]

References

[1].DubueJD,etal.IntrahippocampalAnisomycinImpairsSpatialPerformanceontheMorrisWaterMaze.JNeurosci.2015Aug5;35(31):11118-11124.
[2].YouP,etal.InvitroandinvivoevaluationofanisomycinagainstEhrlichascitescarcinoma.OncolRep.2013,29(6),2227-2236.
[3].MonaghanD,etal.InhibitionofproteinsynthesisandJNKactivationarenotrequiredforcelldeathinducedbyanisomycinandanisomycinanalogues.BiochemBiophysResCommun.2014Jan10;443(2):761-767.

PreparingStockSolutions

ConcentrationVolumeMass	1mg	5mg	10mg

1mM	3.7692mL	18.8459mL	37.6918mL
5mM	0.7538mL	3.7692mL	7.5384mL
10mM	0.3769mL	1.8846mL	3.7692mL

Pleaserefertothesolubilityinformationtoselecttheappropriatesolvent.

References

[1].DubueJD,etal.IntrahippocampalAnisomycinImpairsSpatialPerformanceontheMorrisWaterMaze.JNeurosci.2015Aug5;35(31):11118-11124.
[2].YouP,etal.InvitroandinvivoevaluationofanisomycinagainstEhrlichascitescarcinoma.OncolRep.2013,29(6),2227-2236.
[3].MonaghanD,etal.InhibitionofproteinsynthesisandJNKactivationarenotrequiredforcelldeathinducedbyanisomycinandanisomycinanalogues.BiochemBiophysResCommun.2014Jan10;443(2):761-767.

MolecularWeight

265.31

Formula

C₁₄H₁₉NO₄

CASNo.

22862-76-6

Storage

Powder	-20°C	3years
	4°C	2years
Insolvent	-80°C	6months
	-20°C	1month

Shipping

RoomtemperatureincontinentalUS;mayvaryelsewhere

Solvent&Solubility

10mMinDMSO

*"<1 mg/ml"="" means="" slightly="" soluble="" or="" insoluble.="" "≥"="" means="" soluble,="" but="" saturation="">

Purity:98.03%

SelectBatch: