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当前位置： 首页 > 产品中心 > Small_molecule > Medchemexpress/酒石酸去甲肾上腺素一水合物（同义词：酒石酸去甲肾上腺素一水合物）/HY-13715B/5g
商品详细Medchemexpress/酒石酸去甲肾上腺素一水合物（同义词：酒石酸去甲肾上腺素一水合物）/HY-13715B/5g
Medchemexpress/酒石酸去甲肾上腺素一水合物（同义词：酒石酸去甲肾上腺素一水合物）/HY-13715B/5g
Medchemexpress/酒石酸去甲肾上腺素一水合物（同义词：酒石酸去甲肾上腺素一水合物）/HY-13715B/5g
商品编号： HY-13715B-500mg
品牌： MedChemExp
市场价： ¥1300.00
美元价： 780.00
产地： 美国(厂家直采)
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产品分类： 小分子
公司分类： Small_molecule
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商品介绍
Norepinephrinebitartratemonohydrateisaβ1-selectiveadrenergicreceptoragoNISTwithEC50of5.37μM.
Description

Norepinephrinebitartratemonohydrateisaβ1-selectiveadrenergicreceptoragonistwithEC50of5.37μM.

IC50&Target

EC50:5.37μM(β1-selectiveadrenergicreceptor)[1]

InVitro

Norepinephrine(NE)bitartratemonohydrateisgenerallyconsideredtobeaβ1-subtypeselectiveadrenergicagonist.Norepinephrine(NE)alsohasdirectactivityattheβ2-adrenoceptorinhigherconcentrations[1].ADIpocytesfromtheinguinalfatpad(iWA)ortheinterscapularfatpad(BA)areisolatedfromneonatalwild-typeC57BL/6Jmiceandcultured.ToexaminetheeffectofactivatingAT2uponβ-adrenergicsignaling,cAMPproductionisfirstassessedinresponsetoNorepinephrine(NE,10µM)withorwithoutCGP(10nM)co-treatment.Norepinephrine(NE)increasescAMPasexpectediniWA,andCGPdoesnotalterthiseffect.Norepinephrine(NE)isalsoknowntoinducelipolysis,andliberatedfattyacidsarerequiredtofunctionallyactivateUCP1proteinandtostimulateheatproduction.CREBphosphorylationatSer133isincreasedafterNorepinephrine(NE)treatmentandsignificantlyattenuatedwithCGPco-treatmentinmouseiWA[2].

ClinicalTrial
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References

  • [1].MacGregorDA,etal.Relativeefficacyandpotencyofbeta-adrenoceptoragonistsforgeneratingcAMPinhumanlymphocytes.Chest.1996Jan;109(1):194-200.

    [2].LittlejohnNK,etal.SuppressionofRestingMetabolismbytheAngiotensinAT2Receptor.CellRep.2016Aug9;16(6):1548-60.

PreparingStockSolutions
ConcentrationVolumeMass1mg5mg10mg
1mM2.9649mL14.8245mL29.6490mL
5mM0.5930mL2.9649mL5.9298mL
10mM0.2965mL1.4824mL2.9649mL
Pleaserefertothesolubilityinformationtoselecttheappropriatesolvent.
CellAssay
[2]

Norepinephrine(NE)isdissolvedinDMSOandstored,andthendilutedwithappropriatemediabeforeuse[2].

Subcutaneouspreadipocytesderivedfroma38-yearoldnon-diabeticfemaledonorareimmortalizedwithTERTandHPVE6/E7.Forthecurrentstudies,astablediploidclone(referredtoascloneB)withconsistentdifferentiationcapacityisisolatedbyringcloning.CellsaregrowninpreadipocytePGM2media.Oncecellsareconfluent,differentiationisinducedbyincubationindifferentiationmediaconsistingofdexamethasone,IBMX,indomethacin,andadditionalinsulin.Cellsaredifferentiatedfor10days.Priortotreatment,mediaisreplacedwithPGM2mediaforonedayandthenswitchedtoserum-freemediaovernightfortreatments.Adipocytesaretreatedfor6hourswithvehicle,Norepinephrine(NE,10μM),CGP(10nM),orNorepinephrine(NE)andCGP[2].MCEhasnotindependentlyconfirmedtheaccuracyofthesemethods.Theyareforreferenceonly.

References

  • [1].MacGregorDA,etal.Relativeefficacyandpotencyofbeta-adrenoceptoragonistsforgeneratingcAMPinhumanlymphocytes.Chest.1996Jan;109(1):194-200.

    [2].LittlejohnNK,etal.SuppressionofRestingMetabolismbytheAngiotensinAT2Receptor.CellRep.2016Aug9;16(6):1548-60.

MolecularWeight

337.28

Formula

C₁₂H₁₉NO₁₀

CASNo.

108341-18-0

Storage
Powder-20°C3years
 4°C2years
Insolvent-80°C6months
 -20°C1month
Shipping

RoomtemperatureincontinentalUS;mayvaryelsewhere

Solvent&Solubility

DMSO:≥30mg/mL

*"<1 mg/ml"="" means="" slightly="" soluble="" or="" insoluble.="" "≥"="" means="" soluble,="" but="" saturation="">

Purity:99.75%