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当前位置： 首页 > 产品中心 > Small_molecule > Medchemexpress/血管紧张素II人类（同义词：血管紧张素II；高血压素Ⅱ；AngⅡ；DRVYIHPF）/HY-13948/10mM*1mL水中
商品详细Medchemexpress/血管紧张素II人类（同义词：血管紧张素II；高血压素Ⅱ；AngⅡ；DRVYIHPF）/HY-13948/10mM*1mL水中
Medchemexpress/血管紧张素II人类（同义词：血管紧张素II；高血压素Ⅱ；AngⅡ；DRVYIHPF）/HY-13948/10mM*1mL水中
Medchemexpress/血管紧张素II人类（同义词：血管紧张素II；高血压素Ⅱ；AngⅡ；DRVYIHPF）/HY-13948/10mM*1mL水中
商品编号： HY-13948-10mg
品牌： MedChemExp
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产品分类： 小分子
公司分类： Small_molecule
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商品介绍
AngiotensinIIhumanisconvertedbyAngiotensinIthroughremovaloftwoC-terminalresiduesbytheenzymeangiotensin-convertingenzyme(ACE).AngiotensinIIismediatedbyAT1andAT2receptors,whichareseventransmembraneglycoproteinswith30%sequencesimilarity.

CustomerValidation

  • •ChinesePharmacologicalBulletin,2017,33(1):63-67.
Description

AngiotensinIIhumanisconvertedbyAngiotensinIthroughremovaloftwoC-terminalresiduesbytheenzymeangiotensin-convertingenzyme(ACE).AngiotensinIIismediatedbyAT1andAT2receptors,whichareseventransmembraneglycoproteinswith30%sequencesimilarity.

IC50&Target

Angiotensinreceptor(ATreceptor)[1]

InVitro

MostoftheknownactionsofAngiotensinII(AngII)aremediatedbyAT1receptors,theAT2receptorcontributestotheregulationofbloodpressureandrenalfunction[1].AngiotensinIIraisesbloodpressure(BP)byanumberofactions,themostimportantonesbeingvasoconstriction,sympatheticnervousstimulation,increasedaldosteronebiosynthesisandrenalactions.OtherAngiotensinIIactionsincludeinductionofgrowth,cellmigration,andmitosisofvascularsmoothmusclecells,increasedsynthesisofcollagentypeIandIIIinfibroblasts,leADIngtothickeningofthevascularwallandmyocardium,andfibrosis.Theseactionsaremediatedbytype1AngIIreceptors(AT1)[2].Atthecellularlevel,responsivenesstoAngiotensinIIisconferredbytheexpressionofthetwoclassesofangiotensinreceptors(AT1andAT2).TheeffectsofAngiotensinIItoincreasebloodpressurearemediatedbyAT1receptors[3].

InVivo

TodistinguishtheAT1receptorpopulationthatiscriticalforthepathogenesisofhypertension,osmoticminipumpsareimplanteds.c.intoeachanimaltoinfuseAngiotensinII(1,000ng/kg/min)continuouslyfor4weeks.AngiotensinIIcauseshypertensionbyactivatingAT1receptorsinthekidneypromotingsodiumreabsorption[3].

References

  • [1].deGasparoM,etal.Internationalunionofpharmacology.XXIII.TheangiotensinIIreceptors.PharmacolRev.2000Sep;52(3):415-72.

    [2].FyhrquistF,etal.RoleofangiotensinIIinbloodpressureregulationandinthepathophysiologyofcardiovasculardisorders.JHumHypertens.1995Nov;9Suppl5:S19-24.

    [3].CrowleySD,etal.AngiotensinIIcauseshypertensionandcardiachypertrophythroughitsreceptorsinthekidney.ProcNatlAcadSciUSA.2006Nov21;103(47):17985-90.

AnimalAdmiNISTration
[3]

Mice[3]
(129×C57BL/6)F1micelackingAT1AreceptorsforAngiotensinIIareused.Themicearefed10gm/daygelled0.25%NaCldietthatcontainsallnutrientsandwater.After1weekofbaselinecollections,theanimalsareimplantedwithosmoticminipumpsinfusingAngiotensinIIandarereturnedtothemetaboliccagefor5moredays.UrinarysodiumcontentisdeterminedbyusinganIL943AutomaticFlamephotometer.After28daysofAngiotensinIIinfusion,heartsareharvested,weighed,fixedinformalin,sectioned,andstainedwithMassontrichrome.Allofthetissuesareexaminedbyapathologist(P.R.)withoutknowledgeofgenotypes.MCEhasnotindependentlyconfirmedtheaccuracyofthesemethods.Theyareforreferenceonly.

References

  • [1].deGasparoM,etal.Internationalunionofpharmacology.XXIII.TheangiotensinIIreceptors.PharmacolRev.2000Sep;52(3):415-72.

    [2].FyhrquistF,etal.RoleofangiotensinIIinbloodpressureregulationandinthepathophysiologyofcardiovasculardisorders.JHumHypertens.1995Nov;9Suppl5:S19-24.

    [3].CrowleySD,etal.AngiotensinIIcauseshypertensionandcardiachypertrophythroughitsreceptorsinthekidney.ProcNatlAcadSciUSA.2006Nov21;103(47):17985-90.

MolecularWeight

1046.18

Formula

C₅₀H₇₁N₁₃O₁₂

CASNo.

4474-91-3

Storage
Powder-80°C2years
 -20°C1year
Insolvent-80°C6months
 -20°C1month
Shipping

RoomtemperatureincontinentalUS;mayvaryelsewhere

Solvent&Solubility

H2O:≥50mg/mL

*"<1 mg/ml"="" means="" slightly="" soluble="" or="" insoluble.="" "≥"="" means="" soluble,="" but="" saturation="">

Purity:99.34%